
iVAPS Therapy Titration Protocol
Indications for iVAPS therapy
•Neuromuscular/restrictive disorders
•COPD
•Obesity hypoventilation
Once a patient is fitted with an
appropriate mask, select the
appropriate mask setting.
Evaluate if Target Pt Rate is adequate:
•If central events persist, increase Target Pt Rate by
1–2 BPM every 20 min as needed
For obstructive apneas:
•Increase EPAP by ≥ 1 cm H
2
O every ≥ 5 min to
eliminate obstructive apneas, hypopneas, snoring
and flow limitation
For SpO
2
< 90% with all
respiratory events eliminated:
•Increase Target Va by 0.3 every ≥ 5 min until
desaturations are resolved
Initial iVAPS settings:
•Set Patient Height (eg, 70 inches for 5’10”)
•Set Target Pt Rate equivalent to patient’s
spontaneous respiratory rate (eg, 18 bpm)
•Set Target Va such that Vt is equal to 6ml/kg IBW
•EPAP = 5 cm H
2
O
•Min PS = 4 cm H
2
O
•Max PS = 20 cm H
2
O
Evaluate and titrate:
•Based on Target Pt Rate, Target Va, Vt, SpO
2
and CO
2
compared to baseline
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iVAPS Titration
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